Team:NMU China/Part Collection
Combatting COVID-19
Naval Medical University CHINA
Our part collection has been designed to synthesize CAR-Ms with specific phagocytic function. The chimeric antigen receptor (CAR) includes protein molecules in extracellular, transmembrane and intracellular domains. We have characterized four different intracellular segments of CAR-M which is believed to be very instructive for the constructing macrophages with different phagocytic intensity and phagocytic specificity. The components of our collection are as follows:
| Name | Type | Description | |
|---|---|---|---|
| Extracellular domains | BBa_K4040019 | Coding | CR3022 scFv |
| Transmembrane domains | BBa_K4040004 | Protein_Domain | CD8 hinge |
| BBa_K4040007 | Protein_Domain | CD8TM | |
| Intracellular domains | BBa_K4040000 | Protein_Domain | Intracellular Domain of the MEGF10 Protein |
| BBa_K4040001 | Protein_Domain | Intracellular Domain of the MERTK Protein | |
| BBa_K4040002 | Protein_Domain | FcRγ | |
| BBa_K4040003 | Protein_Domain | CD3 zeta chain | |
| Composite part | BBa_K4040015 | Composite | CAR-MEGF10 |
| BBa_K4040016 | Composite | CARγ | |
| BBa_K4040017 | Composite | CAR ζ | |
| BBa_K4040018 | Composite | CAR-MERTK |